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Creamy Turkey Tetrazzini (Easy Leftover Turkey Recipe)

This creamy Turkey Tetrazzini is the ultimate Thanksgiving leftover recipe — made with fettuccine, cream of mushroom soup, sour cream, mozzarella, parmesan, and tender shredded turkey. Cozy, simple, and topped with buttery Italian breadcrumbs for the perfect crunch.
Print Recipe
Turkey Tetrazzini
Prep Time:10 minutes
Cook Time:30 minutes
Total Time:40 minutes

Ingredients

Base

  • 12 ounces uncooked fettuccine
  • 2 10.5 oz cans condensed cream of mushroom soup
  • 1 cup sour cream
  • 1 cup water
  • 1 tsp chicken bouillon
  • ½ tsp onion powder
  • ½ tsp garlic powder
  • ½ tsp oregano
  • Pepper to taste
  • 2 cups cooked turkey shredded or chopped
  • 1 cup freshly grated parmesan
  • 2 cups shredded mozzarella

Topping

  • 3 tbsp butter melted
  • ½ cup Italian-style breadcrumbs

Instructions

  • Cook the Pasta: Boil the fettuccine in salted water until just under al dente. Drain and set aside.
  • Make the Sauce: In a 9x13 dish, whisk together the cream of mushroom soup, sour cream, water, chicken bouillon, onion powder, garlic powder, oregano, and pepper until smooth.
  • Add the Cheese and Turkey: Stir in the shredded turkey, parmesan, and 1½ cups of the mozzarella until combined.
  • Combine with Pasta: Add the cooked fettuccine to the sauce mixture and toss until fully coated.
  • Sprinkle the remaining ½ cup mozzarella on top.
  • Make the Topping: In a small bowl, mix the melted butter with the Italian-style breadcrumbs until evenly moistened.
  • Add the Topping: Sprinkle the breadcrumb mixture evenly over the tetrazzini.
  • Bake: Bake at 350°F for 20–25 minutes, or until golden and bubbly around the edges.
  • Serve: Let rest for 5 minutes before serving. Creamy, cozy perfection.
Servings: 6