Cook the pasta: Cook the pasta according to package directions, reserving about 1/2 cup of pasta water in the pot (I just eye-ball this).
Make the roux: Melt butter in a large saucepan over medium heat. Whisk in flour and cook for 3-4 minutes, or until golden brown.
Create the sauce: Gradually whisk in milk, stirring constantly to avoid lumps. Bring to a simmer and cook until thickened, about 5-7 minutes. Season with ground mustard, garlic powder, salt, and pepper. You are ready for cheese once a line stays on the back of your wooden spoon.
Add the cheese: Stir in the shredded cheddar, Gruyère, mozzarella, and Parmesan cheeses until melted and smooth (on low heat).
Combine: Add the cooked pasta and reserved pasta water into your baking dish along with your cheese sauce. Stir to combine. Top with breadcrumbs and Parmesan cheese!
Top and Bake: Bake at 375°F for 5-10 minutes, or until golden brown and bubbly.